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KMID : 0603520000050030135
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 3 p.135 ~ p.143
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Antimutagenic Effects of Genistein in Drosophila Somatic Mutation Assaying System
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Yun Hee-Sun
Park Kun-Young
Lee Won-Ho
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Abstract
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This study was carried out to determine the antimutagenic effects of genistein on the somatic mutagenicity induced by Trp-P-2 and MNNG using Drosophila wing spot test. For this purpose, mutagen alone or mutagen with genistein was administered to the heterozygous (mwh/+) third instar larvae by feeding, and somatic cell mutations were
detected in adult fly wing hairs. Genistein did not show any mutagenicity at the feeding concentrations of 5∼15% in the test system. As the feeding concentration of genistein increased, the mutagenicity induced by Trp-P-2 showed a remarkable inhibition especially in the case of small mwh spots. The antimutagenic effect of genistein on the mutagenicity for the total mwh spot formation induced by Trp-P-2 was observed to be 15.5∼85.7%. In the case of direct mutagen, MNNG, the small mwh spot inhibition was dependent on the dose of genistein, while the large mwh spot inhibition was vice versa. Total mwh spot inhibition rate was somewhat limited, approximately 17.6∼34%, by the mutagenicity induced by MNNG. Therefore, in comparison of antimutagenic effects, the mutagenicities induced by the indirect mutagens were more inhibited by genistein than those of the direct mutagen. These results indicate that genistein have inhibitory effects on the mutagenicity induced by mutagens. It seems to suggest that genistein may exert inhibitory effects on mutagenic and/or carcinogenic properties of DNA damaging agents.
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KEYWORD
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Genistein, Drosophila wing spot test system, Trp-p-2, MNNG
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